Clinical pharmacokinetics of meropenem after the first and tenth intramuscular administration

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Clinical pharmacokinetics of meropenem after the first and tenth intramuscular administration.

We investigated the pharmacokinetics of meropenem after the first and tenth i.m. administration in patients with respiratory tract infections. Ten patients (mean age 63.8 +/- 5.2 years) received meropenem 500 mg tds for at least ten doses, and plasma and urine antibiotic concentrations were determined by microbiological assay. After the first injection a mean peak plasma concentration of 7.93 +...

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Clinical Pharmacology of Meropenem in Neonates: Effects and Pharmacokinetics

     Meropenem, a carbapenem antibiotic, has a broad-spectrum activity and is active against Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influencae, Moraxella catarrhalis, gram-negative enteric bacilli as Escherichia coli, Klebsiella, Enterobacter, Serratia and Pseudomonas aeruginosa. Meropenem has excellent penetration in body tissues and in cerebrospinal fluid (in the presenc...

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clinical pharmacology of meropenem in neonates: effects and pharmacokinetics

meropenem, a carbapenem antibiotic, has a broad-spectrum activity and is active against staphylococcus aureus, streptococcus pneumoniae, haemophilus influencae, moraxella catarrhalis, gram-negative enteric bacilli as escherichia coli, klebsiella, enterobacter, serratia and pseudomonas aeruginosa. meropenem has excellent penetration in body tissues and in cerebrospinal fluid (in the presence of ...

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 1996

ISSN: 0305-7453,1460-2091

DOI: 10.1093/jac/37.4.775